SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL COMPOUNDS USING 2,2-DIPHENYL-1-PICRYLHYDRAZYL

Extractive spectrophotometric methods for determination of terbinafine hydrochloride in pharmaceutical formulations using some acidic triphenylmethane dyes

Three simple and sensitive extractive spectrophotometric methods have been described for the assay of terbinafine hydrochloride either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extrac...

Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin

This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). ...

Spectrophotometric Determination of Cephalosporins in Pharmaceutical Samples

Spectrophotometric Determination of Metronidazole in Pharmaceutical Preparations

A rapid and sensitive spectrophotometric method is proposed for determination of Metronidazole. The method depends on the reduction of Metronidazole molecule with zinc dust and hydrochloric acid flowed by diazotation and coupling with 8-quinolinol to give colored chromogens easily measured spectrophotometrically which has λmax= 437 nm. The experimental conditions were optimized and berr’s law w...

Spectrophotometric Determination of Valacyclovir in Pharmaceutical Formulations

A simple spectrophotometric method has been developed for the estimation of valacyclovir in pharmaceutical preparations. The method is based on the reaction of the valacyclovir with methanolic solution of para dimethyl amino benzaldehyde (PDAB) in acidic condition producing Schiff base having absorption maximum at 400 nm. Beer’s law is obeyed in the concentration of 50-250 μg/mL of valacyclovir...